WebJul 1, 1998 · Excessive vasoconstriction, commonly involving the endogenous peptides, angiotensin II and endothelin, or deficient vasodilatation, often involving nitric oxide (NO), are common mechanisms in hypertension, whether defined as systemic, pulmonary or renal. Table 1 Some rat models of hypertension, cardiac hypertrophy and failure Open in new tab WebApr 21, 2010 · Transverse aortic constriction (TAC) in the mouse is a commonly used experimental model for pressure overload-induced cardiac hypertrophy and heart failure. …
NF-kappaB activation is required for adaptive cardiac hypertrophy
WebApr 11, 2024 · Eight weeks after surgery, pathological cardiac hypertrophy in the TAC mice was mitigated by PINK1 overexpression (Figure 2A). Compared to the sham mice, the … WebOct 4, 2024 · Cardiac hypertrophy is initially a compensatory adaptive response to many cardiovascular diseases including chronic hypertension, aortic stenosis, mitral or aortic regurgitation, myocardial infarction, and genetic hypertrophic cardiomyopathy, among others [ … philip carbon share moneycontrol
Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac …
WebNov 25, 2024 · TAC is a common method to induce cardiac hypertrophy and heart failure in mice by inducing pressure overload. We hypothesized that TAC leads to upregulation of … WebNov 11, 2024 · Although the hypertrophic growth of cardiomyocytes provides short-term benefits, for example, reduces wall stress and sustains cardiac function, it becomes … WebMay 31, 2024 · Mouse cardiac hypertrophy was induced by transverse aortic constriction (TAC), and cardiomyocyte hypertrophy was induced by angiotensin II. Cardiac function was analyzed by echocardiography. The signaling pathway was analyzed by western blot. Protein synthesis was monitored by the incorporation of [ 3 H]-leucine. philip carling