WebSchleinitz et al. identify the order of action of small GTPases in endosome maturation and characterize the topology of the apparatus that drives late endosome-lysosome fusion: the HOPS tethering complex guides fusion by bridging Rab2 on late endosomes with Arl8 on … WebLysosomal trafficking regulator is a vesicular transport protein associated with Chédiak–Higashi syndrome. In melanocytic cells LYST gene expression may be …

A phosphoinositide signalling pathway mediates rapid lysosomal …

Web10 feb. 2024 · Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival and requires HOPS, a conserved heterohexameric tethering complex. On the membranes to be fused, HOPS binds small membrane-associated GTPases and … Web5 aug. 2024 · Surprisingly, the authors also found that the lysosomal GTPase Rab7, which was recently demonstrated by the authors to regulate contacts between mitochondria … boy and the bear redondo

Lysosomal Trafficking Regulator - an overview ScienceDirect Topics

WebMore recently, new TPD strategies have been developed to hijack the lysosomal degradation pathway, the major degradation pathway independent of the proteasome. 6 For example, the technologies harnessing autophagy (autophagosome–lysosomal pathway) have been developed, including the autophagy-targeting chimeras (AUTACs) inducing … WebLysosomes are highly dynamic organelles implicated in multiple diseases. Using live super-resolution microscopy, we found that lysosomal tethering events rarely undergo … Web22 sept. 2016 · To determine whether tetherin also attaches exosomes, we knocked it out and found a 4-fold reduction in plasma membrane-associated exosomes, with a concomitant increase in exosomes discharged into the medium. This phenotype could be rescued by wild-type tetherin but not tetherin lacking its GPI anchor. boy and the beast dvd