Kif18a cin
Web14 mrt. 2024 · A few mitotic proteins have been previously identified as potential targets for eliminating chromosomally instable (CIN) cancer cells. For instance, the mitotic kinesin, … Web14 mrt. 2024 · Targeting of CIN-associated vulnerabilities is an emerging therapeutic strategy in drug development. KIF18A, a mitotic kinesin, has been shown to play a role in maintaining bipolar spindle integrity and promotes viability of CIN cancer cells. To explore the potential of KIF18A, a series of inhibitors was identified.
Kif18a cin
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Web7 mrt. 2024 · In cancers, KIF18A is central to the proliferation of chromosomally unstable tumor cells. Disrupting the action of this protein could interrupt the process of cell division … Web2 jun. 2024 · Background: KIF18A is a kinesin assisting chromosome congression and alignment during mitosis. It is nonessential in normal, euploid cell division but essential …
Web11 jun. 2024 · 3.2.Knockdown of KIF18A suppresses cell proliferation, migration, and invading in EC cells. Under the condition that KIF18A levels were significantly downregulated in siKIF18A-transfected Eca-109 and KYSE-150 cells compared with the siCtrl groups confirmed by qRT-PCR (P < 0.0001) (Fig. 1 C) and WB (Fig. 1 D), we … WebNational Center for Biotechnology Information
Web15 jun. 2024 · KIF18A is overexpressed in a subset of human cancers, and its elevated expression is associated with tumor aggressiveness. Chromosomal instability (CIN) is … Web7 apr. 2024 · Genetic studies from multiple groups have identified the mitotic kinesin, KIF18A, as selectively essential for the proliferation of CIN and aneuploid cells. By …
Web22 feb. 2024 · KIF18A is required for proliferation of CIN cells derived from triple negative breast cancer or colorectal cancer tumors but is not required in near-diploid cells. …
Web在KIF18A缺失后，四倍体细胞相对于二倍体细胞的染色体振荡幅度要大得多（图3e，f）。 缺失 KIF18A 的四倍体细胞中存在超振荡染色体，它们倾向于失去与有丝分裂纺锤体的 … cuore di napoli b\u0026bWeb3 mei 2024 · Background: Glioma is globally recognised as one of the most frequently occurring primary malignant brain tumours, making the identification of glioma biomarkers critically significant. The protein KIF18A (Kinesin Family Member 18A) is a member of the kinesin superfamily of microtubule-associated molecular motors and has been shown to … margin call 123moviesWeb3 mei 2024 · Background: Glioma is globally recognised as one of the most frequently occurring primary malignant brain tumours, making the identification of glioma … cuore disegniWebDependency on KIF18A scales proportionally with the degree of aneuploidy, conferring its unique requirement in cells after extensive CIN [95]. KIF18A is an attractive therapeutic target because it ... margin button on calculatorWeb24 mrt. 2024 · KIF18A, a mitotic kinesin, has been shown to play a role in maintaining bipolar spindle integrity and promotes viability of CIN cancer cells. To explore the … cuore di pizza santa maria delle moleWeb4 sep. 2024 · The human KIF18A ATPase assay was performed. Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. The compounds described in this application were tested for their ability to inhibit KIF18A. The KIF18A ATPase IC 50 (μM) are shown in the following table. margin calcylatorWeb16 feb. 2024 · The protein KIF18A is essential for CIN during the proliferation of cancer cells. Interestingly, the knockout of Kif18A in mice only showed minor defects, indicating … margin call 2