WebCIP2A is cytoplasmic in interphase but, in mitosis, accumulates at DNA lesions as part of a complex with TOPBP1, a multifunctional genome stability factor. Unlike PARP inhibition, … WebNov 11, 2024 · Durocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal …
The role of CIP2A in cancer: A review and update - ScienceDirect
WebFeb 9, 2024 · VDOMDHTMLtml> Daniel Durocher on Twitter: "CIP2A encodes a fascinating protein linked to all kinds of processed but not DNA repair or genome stability so the challenge was to understand why CIP2A was essential for the viability of BRCA1/2-deficient cells." We've detected that JavaScript is disabled in your browser. WebThe CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Durocher and colleagues identify CIP2A through synthetic … orbit for patent search
CIP2A Is Associated with Human Breast Cancer Aggressivity
WebDurocher and colleagues identify CIP2A through synthetic lethal CRISPR screens as a key regulator of adaptive feedback mechanisms controlling chromosomal stability arising from accumulated DNA lesions in BRCA-mutated tumor cells.BRCA1/2-mutated cancer cells adapt to the genome instability caused by their deficiency in homologous recombination … Webformation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. Thus, our data show that CIP2A is a human oncopro-tein that inhibits PP2A and … WebCIP2A is cytoplas- mic in interphase but, in mitosis, accumulates at DNA lesions as part of a complex with TOPBP1, a multifunctional genome stability factor. Unlike PARP inhibition, CIP2A deiciency does not cause ac- cumulation of replication-associated DNA lesions that require HR for their repair. orbit footpad