Doxofylline theophylline
Doxofylline (also known as doxophylline) is a phosphodiesterase inhibiting bronchodilator used in the treatment of chronic respiratory diseases such as asthma and COPD. Like theophylline, it is a xanthine derivative. See more Doxophylline is used to treat chronic respiratory diseases such as asthma and COPD. In animal and human studies, it has shown similar efficacy to theophylline but with significantly fewer … See more Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects. This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on See more • Shukla D, Chakraborty S, Singh S, Mishra B (October 2009). "Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease". Expert Opinion on Pharmacotherapy. 10 (14): 2343–56. See more It is marketed under many brand names worldwide, including: Xiva, An Li Nuo Er, An Sai Ma, Ansimar, Asima, Bestofyline, Chuan Ning, D-Fyal, Dilatair, Doxiba, Doxiva, Doxobid, Doxobron, Doxofilina, Doxofillina, Doxofyllin, Doxoll, Doxophylline, … See more WebDoxofylline is a xanthine molecule that appears to be both bronchodilator and anti-inflammatory with an improved therapeutic window over conventional xanthines such as theophylline and the evidence supporting the effects of doxofylline in the treatment of lung diseases is discussed. Copyright (c) 2010. Published by Elsevier Ltd. Publication types
Doxofylline theophylline
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Web摘要： A sensitive and selective RP-HPLC method for the determination of doxofylline(D)and its related compounds has been developed. Chromatography was carried out on a YWG C_(18)column, and acetonitrile-phosphate buffer(0.62 mol·L~(-1),pH 5.4)in the ratio of 15:85 wasused as the mobile phase,Absorhance at 274 nm was … WebJun 1, 2024 · According to their results, doxofylline exerts a powerful bronchodilator and anti-inflammatory activity, which can be exploited when the inhaled oral corticosteroids are not sufficient to get the...
WebDoxofylline was 10 times less potent that theophylline is its ability to antagonize the cardiodepressant activity induced by adenosine in isolated guinea pig atria. The pharmacodynamic differences between doxofylline and theophylline may bring new insights to the understanding of the mechanisms underlying the positive chronotropic … WebFeb 26, 2013 · Theophylline (dimethylxanthine) has been used to treat airway diseases for more than 80 years. It was originally used as a bronchodilator, but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled β 2 -agonists became more widely used.
Web目的 分析氨茶碱和多索茶碱治疗支气管哮喘的效果.方法 选取淮安工业园区人民医院2016年4月至2024年3月62例支气管哮喘患者,将其随机分为对照组(31例,使用氨茶碱治疗)和观察组(31例,使用多索茶碱治疗),治疗疗程为1周,通过治疗有效率进行对比和分析.结果 对比氨茶碱和多索茶碱治疗支气管哮喘治疗 ...
WebDec 23, 2024 · Doxofylline is found to undergo hepatic metabolism, which accounts for about 90% of total drug clearance. β-hydroxymethyltheophylline had been detected in the serum and urine after the oral administration of 400 mg Doxophylline given in healthy subjects. The circulating metabolite was found to be devoid of any significant …
WebSep 21, 2024 · Theophylline is a drug derived from methylxanthine (a purine derivative) and has smooth muscle relaxant, bronchial dilation, diuretic, cardiac and central nervous system (CNS) stimulant activities. It is naturally present in small amounts in tea and cocoa beans and was initially extracted and synthesized in 1895 and used as a diuretic. the coffee grinderWebOct 27, 2024 · Theophylline has been widely used to treat asthma and COPD since the 1930s, but while effective, it is a drug having a narrow therapeutic window and also many … the coffee guy franchiseWebApr 1, 2008 · 2 Doxofylline is a Xanthine molecule that seems to be both Broncho-dilator and Anti-Inflammatory with an enhanced therapeutic window compared to conventional … the coffee hangar cafeWebAug 3, 2024 · Concerning the secondary endpoints, doxofylline was as effective as theophylline in improving FEV 1, although a trend toward significance suggested that … the coffee harbour utrechtWebTheophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease … the coffee hive manchesterWebDec 4, 2013 · In contrast to theophylline, doxofylline has very low affinity towards adenosine A1 and A2 receptors which explain its better safety profile Doxofylline (7- (l,3-dioxalan-2-ylmethyl)-theophylline) is a drug derived from theophylline which is used in therapy as a bronchodilator, with anti-inflammatory action, in reversible airway obstruction. the coffee hive flettonWebApr 1, 2008 · 2 Doxofylline is a Xanthine molecule that seems to be both Broncho-dilator and Anti-Inflammatory with an enhanced therapeutic window compared to conventional Xanthines such as theophylline and ... the coffee hive ossett