Ctcf and ctcfl in cancer

Author: uwai

August undefined, 2024

WebBACKGROUND: BORIS/CTCFL, a paralog of CTCF and member of the cancer-testicular antigen family, is abnormally activated in multiple cancers. OBJECTIVE: We investigated … WebIn ovarian cancer CTCFL expression indeed correlates with advanced stage and decreased survival . In other tumor types CTCFL expression has also been detected, although expression data have been contradictory . According to the TCGA data, CTCFL is mainly expressed in ovarian cancer (Supplementary Figure 2).

Pan-cancer analysis and experimental validation of DTL as a …

Webjayreese: Regen BioPharma Acquires Issued Patent and Preclinical Data Package for Targeting Cancer Stem Cell Regen Has Raised Almost $700,000 From "Angel" In... WebThe LOF of CTCF or cohesin in cancer may cause activation of oncogenes through altering chromatin loops (Fig. 4). CTCF is frequently mutated in endometrial carcinoma, head … solarpals.org

Regen BioPharma Inc. (RGBP): Regen BioPharma Acquires Issued …

WebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, … WebCTCFL; Zinc finger protein CTCF-T; cancer/testis antigen 27; dJ579F20.2; Description CTCFL, a testis-specific DNA binding protein containing 11 C2H2-type zinc fingers, … WebSmits et al. report that TLX3 chromosomal translocations in T cell acute lymphoblastic leukemia patients recurrently include intervening CTCF-binding sites in the breakpoint area. Pressure to acquire inactivating aberrations in CTCF abrogate consequential enhancer insulation that promotes TLX3 promoter to BCL11B enhancer looping boosts higher … slusalice win win

Targeting CTCFL/BORIS for the immunotherapy of cancer

BORIS: a key regulator of cancer stemness - Cancer Cell …

WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The … WebApr 10, 2024 · Pan-cancer bioinformatics analysis showed that the expression of DTL was correlated with the prognosis, immunotherapy, and clinical indexes in various cancers. ... NRF1, E2F4, STA T3, CTCF, CTCFL ... slusalice huaweiWebAug 4, 2024 · Pancreatic cancer’s poor prognosis is caused by distal metastasis, which is associated with epigenetic changes. However, the role of the 3D epigenome in pancreatic cancer biology, especially its metastasis, remains unclear. ... Notably, all sets of NDRs had CTCF and CTCFL motifs, which was consistent with the fact that CTCF is a vital ... slusalice wikipedia

"WebMay 4, 2024 · In recent years, the most extensively studied disease related to CTCF protein is cancer. Debaugny and Skok reviewed the oncogenic roles of CTCF and CTCFL (CTCF-like or BORIS; the paralog of CTCF, see below section for BORIS). Human IDH gene mutant gliomas exhibit DNA hypermethylation, which ... " - Ctcf and ctcfl in cancer

Ctcf and ctcfl in cancer

Cancer-specific CTCF binding facilitates oncogenic …

WebNational Center for Biotechnology Information WebMar 29, 2024 · CTCF and CTCFL in cancer. Dynamic regulation of CTCF stability and sub-nuclear localization in response to stress. Defining the relative and combined contribution …

Did you know?

WebNov 2, 2024 · However, in cancer, CTCF is substituted by CTCFL/BORIS, depicted as a blue circle, shutting down the transcription of these tumor suppressor genes through activation of anti-sense transcripts. The … WebMay 11, 2024 · Ubiquitously expressed CTCF is involved in numerous cellular functions, such as organizing chromatin into TAD structures. In contrast, its paralog, CTCFL, is …

http://www.cancerindex.org/geneweb/CTCFL.htm WebCTCF-mediated enhancer blocking is conserved from Drosophila to man (Moon et al. 2005) Antisense transcription of triplet repeats is constrained by CTCF (Cho et al. 2005) Boundaries between X inactivation and escape of inactivation bind CTCF (Filippova et al. 2005) CTCF antagonizes with CTCFL at the cancer testis gene MAGE-A1 (Vatolin et al. …

WebAug 12, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls … WebApr 4, 2024 · CTCF provided by HGNC Official Full Name CCCTC-binding factor provided by HGNC Primary source HGNC:HGNC:13723 ... LncRNA PCGEM1 promotes colorectal cancer cell proliferation and migration in positive feedback loop through PCGEM1/miR-433-3p/CTCF axis. ... CTCFL paralog. NCBI Reference Sequences (RefSeq) Go to the top of …

WebAug 31, 2016 · A common aberration in cancer is the activation of germline-specific proteins. The DNA-binding proteins among them could generate novel chromatin states, not found in normal cells. The germline-specific transcription factor BORIS/CTCFL, a paralog of chromatin architecture protein CTCF, is often erroneously activated in cancers and …

WebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ... slur word definitionWebApr 1, 2024 · In this regard, BORIS (CTCFL), a CTCF paralog, is a promising cancer biomarker that is overexpressed and controls transcription in several cancer types, mainly in OC. slus boxWebSep 15, 2024 · Identification of cancer-specific CTCF binding patterns in the human genome. a Distribution of coefficient of variation of chromatin accessibility at different genomic features, calculated using DNase-seq data from over 60 cell lines from ENCODE.b Distribution of occupancy score for all 688,429 union CTCF binding sites (blue), and … solar panel 100w price in indiaWebOct 1, 2024 · Using the Kaplan Meier plotter the prognostic significance of mRNA levels of CTCFL in gastric, breast, and ovarian cancer were interrogated, similarly to the respective levels of CTCF. In gastric cancer high CTCFL mRNA expression levels are associated with worse OS compared with gastric cancers having low CTCFL mRNA expression (HR = … solar paint that generates electricityWebNov 15, 2013 · Estrogens play a key role in breast cancer, with 60-70% of the cases expressing estrogen receptors (ERs), which are encoded by the ESR1 gene. CTCFL, a paralogue of the chromatin organizer CTCF, is a potential biomarker of breast cancer, but its expression in this disease is currently controversial. A positive correlation has been … slur your speechWebCancer; Cell Biology; Stem Cells & Development; Metabolic & Cardiovascular Disease; ... 我们为您找到 ctcf 的 1 个相关产品结果。 ... Synonyms: CTCFL;BORIS;CT27;CTCF-T;HMGB1L1;dJ579F20.2. Type: Rabbit Polyclonal Antibody (1) 加入对比（最多5 ... solar paint for houseWebApr 1, 2024 · CTCF and CTCFL in cancer. CTCF plays a key role in organizing chromatin into TAD structures but it can also function as a transcription factor. CTCFL (CTCF-like), … solar panals instorlers bury st edmunds 5 kw